disease

Alzheimer's Disease

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Alzheimer's Disease: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12228Connections

17Hypotheses

30Analyses

50Outgoing

50Incoming

Summary

Alzheimer's Disease is a disease characterized by neurodegeneration research. Key relationships include: associated with, biomarker for, contributes to. Associated with CHIP, Chronic Bacterial Infections, Chronic Kidney Disease. Connected to 239 entities in the SciDEX knowledge graph.

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Disease Info

Associated Genes	SNCA, Connexin43, MMP2, NR3C1, Annexins, Amyloid-Beta, Tau, IGF2
Therapeutic Agents	CI-994, β-Sitosterol, Bispecific Antibodies, Aloe-Emodin, Shuangxia Decoction, Melatonin
SciDEX Hypotheses	70 hypotheses
KG Connections	1091 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Alzheimer_s_Disease["Alzheimer's Disease"] -->|"biomarker for"| Amyloid_beta_1_42["Amyloid-beta 1-42"]
    Alzheimer_s_Disease["Alzheimer's Disease"] -->|"biomarker for"| Tau_Protein["Tau Protein"]
    Alzheimer_s_Disease["Alzheimer's Disease"] -->|"biomarker for"| Hyperphosphorylated_Tau["Hyperphosphorylated Tau"]
    Alzheimer_s_Disease["Alzheimer's Disease"] -->|"associated"| Neural_Cell_Culture["Neural Cell Culture"]
    Alzheimer_s_Disease["Alzheimer's Disease"] -->|"associated"| Circadian_Rhythm["Circadian Rhythm"]
    Alzheimer_s_Disease["Alzheimer's Disease"] -->|"associated"| Neural_Cell_Culture_Model["Neural Cell Culture Model"]
    Connexin43["Connexin43"] -->|"associated"| Alzheimer_s_Disease["Alzheimer's Disease"]
    Protective_Genetic_Variants["Protective Genetic Variants"] -->|"protects against"| Alzheimer_s_Disease["Alzheimer's Disease"]
    Proteomics_Technologies["Proteomics Technologies"] -->|"involved in"| Alzheimer_s_Disease["Alzheimer's Disease"]
    Bispecific_Antibodies["Bispecific Antibodies"] -->|"treats"| Alzheimer_s_Disease["Alzheimer's Disease"]
    style Alzheimer_s_Disease fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (5085)

Target	Relation	Type	Str
Amyloid-beta 1-42	biomarker_for	biomarker	0.95
Hyperphosphorylated Tau	biomarker_for	biomarker	0.95
Neural Cell Culture	associated_with	cell_type	0.95
Circadian Rhythm	associated_with	process	0.95
Neural Cell Culture Model	associated_with	cell_type	0.95
Neurodegeneration	causes	process	0.95
Somatic Genomic Changes	associated_with	process	0.95
Neuroinflammation	associated_with	process	0.95
AMYLOID-BETA	associated_with	protein	0.95
TAU	associated_with	protein	0.95
Toxic Protein Accumulation	associated_with	process	0.95
Amyloid/Tau Pathways	involved_in	pathway	0.95
Cognitive Impairment	causes	phenotype	0.95
Mitochondrial Dysfunction	associated_with	process	0.95
Neurodegenerative Diseases	associated_with	disease	0.95
Cognitive Decline	causes	phenotype	0.95
Memory Loss	causes	phenotype	0.95
Amyloid-Beta Plaques	associated_with	biomarker	0.95
Tau Tangles	associated_with	biomarker	0.95
Dementia	causes	disease	0.95
Blood-Based Biomarkers	biomarker_for	biomarker	0.95
Genetic Mutations	causes	mechanism	0.95
β-amyloid	associated_with	protein	0.95
Sleep Disturbances	causes	phenotype	0.93
Sleep Disruption	associated_with	phenotype	0.90
NREM Sleep	causes	phenotype	0.90
HDAC I Availability	causes	biomarker	0.90
Synapse Loss	causes	phenotype	0.90
Single Neurons	associated_with	cell_type	0.90
Microglia	associated_with	cell_type	0.90
Disease-Associated Microglia	associated_with	cell_type	0.90
Neuronal Fate Instability	causes	phenotype	0.90
Glymphatic System Impairment	associated_with	process	0.90
Sphingolipid Metabolism	associated_with	pathway	0.90
Neurons	targets	cell_type	0.90
synapse formation	suppresses	process	0.90
cerebral cortex	causes	brain_region	0.90
brain_region	associated_with	brain_region	0.90
Cerebral Hypometabolism	causes	phenotype	0.90
Neurogenesis	inhibits	process	0.85
Neurofilament Light	biomarker_for	biomarker	0.85
Somatic Mutations	biomarker_for	biomarker	0.85
Insulin Resistance	associated_with	process	0.85
TDP43 Loss	associated_with	mechanism	0.85
Heart-Brain Axis	involved_in	pathway	0.85
Neurofibrillary Tangles	causes	biomarker	0.85
Induced Neurons	associated_with	cell_type	0.85
Sleep Disturbances	associated_with	phenotype	0.85
Globus Pallidus	associated_with	brain_region	0.85
excitation-inhibition ratio	associated_with	phenotype	0.85

Incoming (7143)

Source	Relation	Type	Str
AD Neuropathologic Change	causes	process	0.98
Neurofibrillary Tangles	involved_in	mechanism	0.98
Amyloid Plaques	involved_in	mechanism	0.98
Connexin43	associated_with	protein	0.95
Protective Genetic Variants	protects_against	biomarker	0.95
Proteomics Technologies	involved_in	process	0.95
Bispecific Antibodies	treats	drug	0.95
Amyloid-Beta	contributes_to	protein	0.95
TET2	protects_against	gene	0.95
APOE4	risk_factor_for	protein	0.95
Gene Replacement-Alzheimer's Disease (GR-AD) Project	associated_with	process	0.95
Amyloid-Beta	causes	protein	0.95
Tau	causes	protein	0.95
Anxiety	associated_with	phenotype	0.95
Depression	associated_with	phenotype	0.95
Cognitive Impairment	associated_with	phenotype	0.95
Amyloid Beta	contributes_to	protein	0.95
Structural Variations	contributes_to	mechanism	0.95
Beta-Amyloid	biomarker_for	biomarker	0.95
Phosphorylated Tau	biomarker_for	biomarker	0.95
APOE ε4 Allele	risk_factor_for	biomarker	0.95
Chronic Sleep Deprivation	associated_with	process	0.95
Somatic Genomic Changes	associated_with	process	0.95
Tau	biomarker_for	protein	0.95
Apoe4	risk_factor_for	biomarker	0.95
Neuroinflammation	biomarker_for	process	0.95
APOE Ε4 ISOFORM	risk_factor_for	protein	0.95
Dam	associated_with	cell_type	0.95
Circadian Clock	associated_with	process	0.95
ABETA	causes	protein	0.95
TAU	causes	protein	0.95
TAU	biomarker_for	protein	0.95
AΒ	causes	protein	0.95
Transcriptomic Data	biomarker_for	biomarker	0.95
Proteomic Data	biomarker_for	biomarker	0.95
Metabolomic Data	biomarker_for	biomarker	0.95
Lipidomic Data	biomarker_for	biomarker	0.95
TAU PROTEIN	associated_with	protein	0.95
BIN1	associated_with	gene	0.95
MAPT	associated_with	protein	0.95
AMYLOID BETA	biomarker_for	protein	0.95
Protein Aggregation	causes	process	0.95
Apoptosis	associated_with	process	0.95
Microglial Immunometabolism	involved_in	process	0.95
Dystrophic Neurites	associated_with	phenotype	0.95
AMYLOID-BETA	associated_with	protein	0.95
Tau Pathology	associated_with	process	0.95
NF-KB	involved_in	protein	0.95
AMYLOID BETA	contributes_to	protein	0.95
Neurofibrillary Tangles	contributes_to	phenotype	0.95

Targeting Hypotheses (17)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound to restore hippo	0.709	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound with 40Hz gamma	0.689	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.625	Alzheimer's disease	Circuit-level neural dynamics in neurode

Closed-loop transcranial focused ultrasound to restore hippo	0.614	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.612	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.566	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic viral vector delivery via tFUS-mediated blood-br	0.557	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.554	Alzheimer's disease	Circuit-level neural dynamics in neurode
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive	0.512	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.508	Alzheimer's disease	Circuit-level neural dynamics in neurode
Microglial TREM2 downregulation impairs damage-associated re	0.507	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
GAS6/TAM Axis Activation Stabilizes Blood-Brain Barrier to R	0.498	neuroinflammation	Why do TAM receptors protect against neu
C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV I	0.497	neurodegeneration	Are interneuron oscillation deficits com
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo	0.493	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Epigenetic Memory Reprogramming for Alzheimer's Disease	0.467	neurodegeneration	CRISPR-based therapeutic approaches for

Mentioning Analyses (30)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
External fixation versus reverse shoulder arthroplasty for proximal humerus frac [PMID:41940987]	Vadalà A, Benelli C, Suraci F, Carta B,	Arch Orthop Trauma Surg	2026
Gray matter structural and molecular signatures in Alzheimer's disease and late- [PMID:41419068]	Yang S, Wang X, Yan Y, Zhang J, Wei Y et	J Affect Disord	2026
Cytomegalic parvalbumin neurons in fetal cases of hemimegalencephaly. [PMID:39973610]	Gelot AB, Draia-Nicolau TO, Mathieu R, S	Epilepsia	2025
Brain connectivity and transcriptional changes induced by rTMS in first-episode [PMID:40274783]	Guan M, Xie Y, Wang Z, Miao Y, Li X et a	Transl Psychiatry	2025
Single-cell RNA sequencing of adult primate neocortex reveals the regulatory dyn [PMID:40385068]	Zhang C, Xie Z, Wang N	Am J Transl Res	2025
Human stem cell-derived GABAergic interneuron development reveals early emergenc [PMID:40651475]	Bershteyn M, Zhou H, Fuentealba L, Chen	Neuron	2025
Enhancer AAV toolbox for accessing and perturbing striatal cell types and circui [PMID:40403704]	Hunker AC, Wirthlin ME, Gill G, Johansen	Neuron	2025
Forebrain assembloids support the development of fast-spiking human PVALB+ corti [PMID:40695284]	Walsh RM, Crabtree GW, Kalpana K, Jubier	Neuron	2025
Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social [PMID:40320404]	Qi C, Sima W, Mao H, Hu E, Ge J et al.	Nat Commun	2025
Distinct dendritic integration strategies control dynamics of inhibition in the [PMID:40592329]	Morabito A, Zerlaut Y, Dhanasobhon D, Be	Neuron	2025
Targeting SARM1 improves autophagic stress-induced axonal neuropathy. [PMID:37561040]	Kim HR, Lee HJ, Jeon Y, Jang SY, Shin YK	Autophagy	2024
Integrated multimodal cell atlas of Alzheimer's disease. [PMID:39402379]	Gabitto MI, Travaglini KJ, Rachleff VM,	Nat Neurosci	2024
Identification of early Alzheimer's disease subclass and signature genes based o [PMID:39650656]	Wang W, Lu J, Pan N, Zhang H, Dai J et a	Front Immunol	2024
Cortical somatostatin long-range projection neurons and interneurons exhibit div [PMID:38086373]	Fisher J, Verhagen M, Long Z, Moissidis	Neuron	2024
Locus Coeruleus-Dorsolateral Septum Projections Modulate Depression-Like Behavio [PMID:38155473]	Zhang Q, Xue Y, Wei K, Wang H, Ma Y et a	Adv Sci (Weinh)	2024
Somatostatin and the pathophysiology of Alzheimer's disease. [PMID:38484981]	Almeida VN	Ageing Res Rev	2024
Somatostatin interneurons control the timing of developmental desynchronization [PMID:38599213]	Mòdol L, Moissidis M, Selten M, Oozeer F	Neuron	2024
De novo gene synthesis by an antiviral reverse transcriptase. [PMID:39116258]	Tang S, Conte V, Zhang DJ, Žedaveinytė R	Science	2024
Signature morphoelectric properties of diverse GABAergic interneurons in the hum [PMID:37824669]	Lee BR, Dalley R, Miller JA, Chartrand T	Science	2023
Novel App knock-in mouse model shows key features of amyloid pathology and revea [PMID:35690868]	Xia D, Lianoglou S, Sandmann T, Calvert	Mol Neurodegener	2022

Alzheimer's Disease

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

CBS/PSP Supplements Guide

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome